Bhan et al. (2014) demonstrate that EZH2 is transcriptionally induced by estradiol in cultured breast cancer cells and in the mammary glands of ovariectomized rats. Similar to estradiol, DES-induced EZH2 expression is coordinated by ERs, MLLs and CBP/P300. These studies suggest that EZH2 is potentially dysregulated upon exposure to EDCs, and provides a direct link between EDC-induced nuclear hormone receptor signaling and modulation of the epigenetic machinery (Bhan et al., 2014). This evidence concerns the gene EZH2 and breast carcinoma.