These data altogether suggested a model whereby IQGAP1 scaffolds MAPK components (c-Raf, MEK1/2 and ERK1/2) at the plasma membrane via Melusin and FAK to form a supercomplex to regulate MAPK-ERK signaling and cardiac hypertrophy (Figure 1). This evidence concerns the gene ITGB1BP2 and cardiac hypertrophy.