Interestingly, loss of function studies in mouse models deficient in MAPK scaffold proteins bound to the sarcomere, such as FHL1 and ANKRD1, suggest a detrimental role in Gαq and phenylephrine-induced cardiac hypertrophy, respectively, while studies on MAPK scaffold proteins bound to the plasma membrane, such as IQGAP1 and Sur-8, suggest a protective role in mechanical induced-cardiac hypertrophy. This evidence concerns the gene PROS1 and cardiac hypertrophy.