In adult cardiac muscle ANKRD1 expression is developmentally downregulated but was reported to increase in animal models of cardiac hypertrophy and human patients with various forms of cardiomyopathy leading to heart failure (Arber et al., 1997; Kuo et al., 1999; Aihara et al., 2000; Maeda et al., 2002; Zolk et al., 2003). Here, ANKRD1 is linked to cardiac hypertrophy.