MAPT and motor neuron disorder: In FTD, the classic approach subdivided the frontotemporal anatomic atrophy with regards to the concomitant histopathological findings, that is: Pick disease when tau-positive intraneuronal inclusions were found, FTD with motor neuron disease when tau-negative-ubiquitine-positive intracellular inclusions were present in motor neurons or Frontotemporal Lobar Degeneration when no particular histopathological features were observed (Broe et al., 2004).