In FTD, the classic approach subdivided the frontotemporal anatomic atrophy with regards to the concomitant histopathological findings, that is: Pick disease when tau-positive intraneuronal inclusions were found, FTD with motor neuron disease when tau-negative-ubiquitine-positive intracellular inclusions were present in motor neurons or Frontotemporal Lobar Degeneration when no particular histopathological features were observed (Broe et al., 2004). This evidence concerns the gene MAPT and frontotemporal dementia.