In 2012, Dengjel used quantitative proteomics to identify VPS35 as a stimulus-dependent interacting partner of autophagosomes in human breast cancer cells, while a more recent study demonstrated that VPS35 directly interacts with and retrieves Atg8 in Magnaporthe oryzae (Dengjel et al., 2012). This evidence concerns the gene VPS35 and breast carcinoma.