While we did not observe alterations of SNCA-targeting miRNAs, miR-7 and miR-153 (Junn et al., 2009; Doxakis, 2010), two miRNAs shown be regulated by LRRK2 (let-7i-3p/5p and miR-184 Gehrke et al., 2010) and one miRNA experimentally shown to target LRRK2 expression (miR-1224 Sibley et al., 2012), were observed to be down-regulated in PD. The gene discussed is LRRK2; the disease is Parkinson disease.