GRN and dementia: In particular, a recent study investigating brain network connectivity with functional resting state MRI (Premi et al., 2014) utilizing three measures of both local and global connectivity (the regional homogeneity, the fractional amplitude of low frequency fluctuation and the degree centrality) has shown that parietal lobes are affected very early in GRN mutation carriers, so that the notion of fronto-parietal dementia for PGRN related disease should be considered.