Because previous work has illustrated that the effects of COMT may emerge in older adults and individuals at risk for cognitive decline (de Frias et al., 2005; Lindenberger, 2008; Nagel et al., 2008; Josefsson et al., 2012; Papenberg et al., 2014), we performed a secondary analysis, excluding the younger age cohorts while controlling for demographic factors and retest effects. This evidence concerns the gene COMT and Mental deterioration.