Our knowledge is expected to increase thanks to amplification of genes such as EGFR in glioblastoma, loss of alleles on chromosomes 1p and 19p in oligodendroglioma, and mutations in genes such as in p53 and IDH1 in low-grade astrocytoma that progresses to malignant astrocytoma. Here, TP53 is linked to astrocytoma (excluding glioblastoma).