In keeping with the role of MMP-9 and TIMP-1 in the pathogenesis of stroke, mild hypothermia provided protection from ischemia/reperfusion injury via decreasing the expression of MMP-9 (Burk et al., 2008; Zhao et al., 2013) and TIMP-1 (Zhao et al., 2013). The gene discussed is TIMP1; the disease is Stroke.