This drug induced oxidation of proteins involved in energy metabolism in SKNSH neuroblastoma cells, seen as effects on mitochondrial ribosomal protein S22 (MRPS22), mitochondrial malate dehydrogenase (MDH), calumenin (CALU), pyruvate kinase (PK1), and 3-oxoacid CoA transferase (OXCT1; Walss-Bass et al., 2008). This evidence concerns the gene MDH2 and neuroblastoma.