Just as ubiquilin2-positive inclusions have become a general observation in both familial and sporadic ALS, so have p62-positive inclusions (Mizuno et al., 2006; Deng et al., 2011a), thus signifying the requirement for protein clearance pathways in the maintenance of neuronal health (Fecto and Siddique, 2012). The gene discussed is SQSTM1; the disease is amyotrophic lateral sclerosis.