MIAT and schizophrenia: Down-regulated in response to neuronal activation and involved in schizophrenia-associated alternative splicing (Barry et al., 2014). Decreased in the medial prefrontal complex following fear conditioning and knockdown of promoted stress reactivity and anxiety-like behavior (Spadaro et al., 2015). Neurogenic commitment and neuronal survival, sustained overexpression of Miat promoted neuronal death (Aprea et al., 2013).