Moreover, one of the ITIMs in the LILRB1 was reported to possess an immunoreceptor tyrosine-based switch motif (ITSM; SXVXXV), and the binding of adaptors signaling lymphocyte activation molecule-associated protein and Ewing’s sarcoma-associated transcript to an ITSM can convert receptors from inhibitory to activating function (Li et al. 2009). The gene discussed is LILRB1; the disease is Ewing sarcoma.