To evaluate inflammasome activity in murine CF, we infected Cftr–/– and C57BL/6 mice intranasally with A. fumigatus or intratracheally with P. aeruginosa and evaluated IL-1β, IL-1α and IL-18 production, caspase-1 cleavage and expression of NLRP3 or NLRC4 for their involvement in response to both A. fumigatus23 and P. aeruginosa17, 18, 19, 20, 21, 22. The gene discussed is IL18; the disease is cystic fibrosis.