AKT1 and cancer: Moreover, the inhibitory effect of the overexpression of miR-634 on cell survival in cancer cells has already been demonstrated: that the overexpression of miR-634 activates the mitochondrial apoptotic pathway by direct concurrent targeting of genes associated with mitochondrial homeostasis, anti-apoptosis, antioxidant ability and autophagy in a model of esophageal squamous cell carcinoma35, and that miR-634 is one of the most effective miRNAs to induce apoptosis and inhibit the level of p-Akt in HER2 positive breast cancer36.