Among the top hub genes of the ER-MGIN we identified a potential biomarker for ovarian cancer (PDIA3)30, 31, a BRCA1 mutation-dysregulated gene (HNRNPA2B1)32, and a gene implied to be associated with transition from normal into cancerous state in endometrial cancer, another hormone-related cancer (DDX3X)33 (Supplementary Fig. S10 and Supplementary Table S6B). The gene discussed is PDIA3; the disease is ovarian carcinoma.