BDNF and neuroblastoma: Together, the aforementioned data are consistent with the idea that CSB inactivation results in the sub-optimal expression of gene regulatory networks that are activated by BDNF during differentiation of neuroblastoma cells and that CSB function can be, at least partially, bypassed by artificially re-activating these networks, through SYT9, BDNF, or BDNF-mimicking drugs such as 7,8-DHF and amitriptyline.