However, small-molecule agonists of TRKB, such as 7,8-dihydroxyflavone (7,8-DHF) and amitriptyline, can mimic BDNF stimulation, and recent results suggest that these might be promising therapeutic tools for the treatment of neurological disease (Jang et al., 2010, Jiang et al., 2013, Cong et al., 2015, Zhao et al., 2015). This evidence concerns the gene BDNF and nervous system disorder.