NTRK2 and nervous system disorder: However, small-molecule agonists of TRKB, such as 7,8-dihydroxyflavone (7,8-DHF) and amitriptyline, can mimic BDNF stimulation, and recent results suggest that these might be promising therapeutic tools for the treatment of neurological disease (Jang et al., 2010, Jiang et al., 2013, Cong et al., 2015, Zhao et al., 2015).