Induction of autophagy and clearance of aggregates underlie the beneficial effects of rapamycin in mouse models of Alzheimer’s disease (AD) [10, 98], HD [80], SCA3 [55], and PD [19], and in mice overexpressing TDP43 modeling frontotemporal dementia [102]. This evidence concerns the gene TARDBP and early-onset autosomal dominant Alzheimer disease.