TP53 and colonic neoplasm: Later, in the 2015, Jiang FZ et al. found that the overexpression of different mutp53 proteins (C135Y, R175H, R248Q, R273H) in p53-null endometrial carcinoma cell lines (HEC-50) disrupts p68-Drosha complex assembly and inhibits the recruitment of Drosha on pri-miRNA-26a1 [56], confirming in part the results obtained by Suzuki on colon cancer cells [52].