To assess the effects of ferulic acid therapy on TNF-Tg mice with arthritis, we treated a cohort of TNF-Tg mice for 12 weeks and examined changes in lymphatic flow, lymphatic contraction frequency, LSMC gene expression, synovitis, and focal erosions by NIR-ICG imaging, qPCR, and histology. Here, TNF is linked to arthritic joint disease.