As shown in Fig. 3d, potent LSD1 inhibitors 1–3 were able to largely reduce the numbers of cell colonies with EC50 values of 0.43, 0.52, and 0.48 μM, respectively, showing that LSD1 inhibition can impair the leukemia stem-like cells in the clinical sample. The gene discussed is KDM1A; the disease is leukemia.