CRCs with chromosomal instability frequently demonstrate loss of heterozygosity (LOH) involving numerous genes, but particularly the APC (Adenomatous Polyposis Coli) and DCC (Deleted in Colorectal Cancer) genes, as well as point mutations in the KRAS (Ki-ras2 Kirsten rat sarcoma) gene. Here, APC is linked to Familial adenomatous polyposis.