Since MYB is a recognised NF‐κB target gene 16 and has NF‐κB binding sites within its promoter (http://bioinfo.lifl.fr/NF‐KB/), it is tempting to speculate that MYB might be activated in a subset of inherited cylindromas as a consequence of aberrant NF‐κB signalling, due to loss of CYLD function. The gene discussed is MYB; the disease is adnexal spiradenoma/cylindroma of a sweat gland.