PIK3CA and cancer: These pathways regulate processes such as cellular proliferation, differentiation, and the cell cycle and include well‐known cancer genes such as ERBB2, EGFR, PIK3CA, and JUN. These observations also are consistent with a recent prospective study that showed enrichment of cancer (and cell adhesion) pathways in blood‐derived DNA methylation profiles for women who developed familial breast cancer (Xu et al, 2013).