TNFAIP1 and PHACE syndrome: Given the association between elevations in BACURD1/KCTD13 gene dosage and psychosis [11], and BACURD2/TNFAIP1 with PHACE syndrome (a congenital condition in which infants present with structural brain abnormalities and seizures) [13], it is plausible that excessive BACURD1/KCTD13 and BACURD2/TNFAIP1 gene expression may have direct, detrimental effects on the formation of cerebral cortical circuitry, and could lead to neurological dysfunction in humans.