With the help of 3C-based technologies, a recent study [6] identified long-range (at megabase distances) interactions between the obesity-associated intronic variants in FTO gene and the promoter region of homeobox gene IRX3, demonstrating it is the expression of IRX3 rather than FTO that is directly linked to body mass and composition. The gene discussed is IRX3; the disease is obesity due to melanocortin 4 receptor deficiency.