As a primary target of the EWS/FLI1 fusion gene characteristic of Ewing’s sarcoma, SOX2 facilitated G1/S phase transition through regulation of key cell cycle factors and restrained cell apoptosis by regulating apoptotic factors in both intrinsic and extrinsic pathways via activation of the PI3K/Akt signaling pathway. Here, SOX2 is linked to Ewing sarcoma.