AKT1 and Ewing sarcoma: The present study identified SOX2 as an upstream regulator in the PI3K/Akt pathway in Ewing’s sarcoma; knockdown of SOX2 reduced expression of PI3K and abolished phosphorylation of Akt to p-Akt in vitro; whereas overexpression of Akt counteracted the variations of downstream proteins caused by silencing of SOX2, thereby negating the effects of SOX2 inhibition on the cell cycle progression and apoptosis.