Because MCF-7 human breast cancer cells expressed both PRL-2 and CNNM3 (5), we tested their proliferation rate with various concentrations of thienopyridone using the xCELLigence system (Fig. 5B) and showed that this small molecule inhibitor was able to decrease cell proliferation (Fig. 5C). The gene discussed is CNNM3; the disease is breast carcinoma.