THY1 and nephritis: However, chronic anti-Thy-1 nephritis in the rat is caused by abnormal deposition of IgG in glomeruli while human IgAN, the most common form of MsPGN, is primarily caused by the deposition of IgA in the glomeruli [13], together with the species and genetic differences between rat and human, therefore the results obtained from this model can not be directly used to predict human IgAN.