THY1 and nephritis: However, the levels of serum creatinine were not significantly changed (p > 0.05) in all drug-treated groups in contrast to that in the Thy-1 group, which demonstrated that irbesartan and Shenhua Tablet of any dose in this study were unable to reduce the level of serum creatinine in rats with anti-Thy-1 nephritis (Fig. 2).