SHANK3 and schizophrenia: Several protein regulating RAC1 such as TIAM1 (T-lymphoma invasion and metastasis-inducing protein 1) and DISC1 (Disrupted in schizophrenia 1) have been associated with psychiatric disorders in genome-wide association studies and the Neurexin-Neuroliginsynaptic complex that is highly linked to SHANK3 [35, 36] found to regulate the schizophrenia-related DISC1/KAL-7/RAC1 “Signalosome” [37].