PCSK9 and familial hypercholesterolemia: PCSK9 inhibitors are approved for patients with heterozygous familial hypercholesterolemia (HeFH), homozygous familial hypercholesterolemia (HoFH), and for patients with atherosclerotic cardiovascular disease (CVD) unable to achieve LDLC goals despite maximal tolerated cholesterol-lowering therapy, including zero dose tolerance (statin intolerance) [1–3].