Co-culture systems using heterologous primary human ADSC (from lipo-aspiration and breast) with immortalized breast tumor cell lines have demonstrated increased tumor proliferation, migration, invasion, EMT and secretion of different factors, e.g., inflammatory cytokines (IL-6, IL-8) and matrix metalloproteinases (MMPs) [65, 66]. This evidence concerns the gene CXCL8 and neoplasm.