KRAS and colorectal carcinoma: Conversely, knockdown of miR-543 promotes the proliferation, invasion and metastasis of CRC cells in vitro and in vivo. Therefore, these results support the notion that the downregulation of miR-543 in CRC cells “contributes to the activation of multiple oncogenic signaling” pathways by upregulating the expression of KRAS, MTA1 and HMGA2, and ultimately results in CRC progression and metastasis.