The spondyloarthropathies are a polygenic disease in which polymorphisms in genes related to the innate immune system are involved: CARD9, TNF receptor family member 1A, TNF receptor superfamily 15 (TNFSF15), IL-1 (IL1A, ILR2), IL-23/IL-17 (IL-23R), signal transducer and activator of transcription 3 (STAT3) [19]. This evidence concerns the gene IL1A and spondyloarthropathy.