STAT3 and systemic lupus erythematosus: In particular, IFN-α/βR signaling results in the recruitment of IRF9 and STAT1, which are involved in the transcription of interferon-stimulated genes (ISGs) and anti-nuclear antibody production in a mouse model of SLE (Thibault et al., 2008), and STAT3, which is involved in the transcription of the IL-10 locus (Benkhart et al., 2000).