EDN1 and Hypertension: The exact mechanisms of VEGFI-induced hypertension are not fully understood but are believed to include endothelial dysfunction, reduced NO generation and vasodilatation, increased endothelin-1 and vasoconstriction, capillary rarefaction, vascular remodelling, and oxidative stress.7, 31, 32, 33, 34, 35, 36 Recent data from animal models and early clinical studies have suggested autonomic nervous system toxicity might also contribute to VEGFI-associated hypertension.37