NEK8 and Renal cyst: Fetuses with total NEK8 loss-of-function mutations (c.47+1G>A, family 3; p.R127*/p.R462*, family 5) presented enlarged cystic kidneys and pancreas associated with proliferative cystic biliary ducts, characteristics of Renal-Hepatic-Pancreatic Dysplasia syndrome (OMIM #208540), as described for the previously reported fetuses with a nonsense mutation [6].