In contrast, Nek8 knockout mice (Nek8tm1Bei) present a mild renal phenotype, with dilated proximal tubules and glomerular cysts [39] and the mouse model with a missense mutation (p.I124Y) in the kinase domain (Nek8roc) exhibits hydroureter, cystic tubular dilations and small glomerular cysts [10]. The gene discussed is NEK8; the disease is Hydroureter.