This is in agreement with the phenotype of Anks6Streaker mice whose Anks6 mutation (p.M187K) decreases the binding to and activation of Nek8 and leads to cystic kidneys, situs inversus and congenital heart defects, thus mimicking the phenotype of patients with NEK8 mutations [10]. This evidence concerns the gene ANKS6 and Renal cyst.