ASPG and acute lymphoblastic leukemia: Clinical studies have indicated an interaction between asparaginase and glucocorticoids in pediatric patients receiving these two critical agents of ALL chemotherapy.[13, 28] Herein, we used a mouse model to confirm the clinical observations that systemic exposure of glucocorticoids was increased by asparaginase treatment, and we showed definitively that asparaginase treatment contributes to the osteonecrotic effect of glucocorticoids.