Both, MYCL and PERI, are closely associated with disturbed glucose metabolism including impaired glucose tolerance [5] and T2DM [6, 7], resulting in functional as well as morphological changes of the heart: Increased MYCL content has been reported to be associated with decreased left ventricular (LV) diastolic functional parameters in lean healthy volunteers following short term caloric restriction [8] and was shown to be an independent predictor of diastolic dysfunction in diabetic patients [9]. This evidence concerns the gene MYCL and Impaired glucose tolerance.