The results showed that the expression levels of EVI1 were significantly up-regulated in HBV-HCC tissues in comparison with the adjacent noncancerous hepatic tissues from the same patient (P < 0.0001, paired-samples t test), however, no significant difference was observed in the expression levels between the HBV-negative HCC tissues and the adjacent noncancerous hepatic tissues (Figure 3C). The gene discussed is MECOM; the disease is hepatocellular carcinoma.