Using KEGG pathway analysis, it was found that Ras activation of RalA leads to engagement of multiple effector pathways (MAPK, ErbB, VEGF, mTOR, Wnt and PI3K-Akt), which are closely correlated with CML pathogenesis and progression (Table S1). Here, MTOR is linked to chronic myelogenous leukemia, BCR-ABL1 positive.