TF and neoplasm: In this study, we report the following set of findings: i) asTF-β1 integrin interactions render PDAC cells significantly more motile; ii) RabMab1-mediated targeting of asTF inhibits basal as well as asTF-potentiated migration of PDAC cells; iii) host flTF and/or asTF contributes to PDAC spread and influences the stromal composition of primary PDAC tumors; iv) tumor-derived asTF is cumulatively a more significant contributor to PDAC progression compared to host-TF.