We re-analyzed a positive SNP detected in single-site analysis of ERCC1, and observed that the two-site combination haplotype showed similar results to the entire six-site combination haplotype for both ERCC1. This simplification showed that the ERCC1 C-C haplotype of rs2298881-rs3212961 increased HCC risk, while the ERCC1 A-C haplotype decreased HCC risk. The gene discussed is ERCC1; the disease is hepatocellular carcinoma.