Among these 39 SNPs, six SNPs in five genes were associated with HCC risk in stage 1, including three risk SNPs (XPA rs10817938, XPC rs1870134 and ERCC2 rs238417) and three protective SNPs (ERCC1 rs2298881 and rs3212961, and ERCC5 rs873601). This evidence concerns the gene ERCC5 and hepatocellular carcinoma.