In the present study, we adopted candidate gene association study strategy with selected 39 potentially functional tag SNPs (tagSNPs) in eight genes involved in NER pathways: XPA, XPC, DDB2, ERCC1, ERCC2, ERCC3, ERCC4 and ERCC5. We determined whether these genes were associated with HCC in the second verification stage, and for the promising SNPs we investigated the effects of the SNPs on the mRNA expression of the corresponding genes. The gene discussed is XPA; the disease is hepatocellular carcinoma.