And we found the OR of “ERCC1 rs2298881 and XPC rs1870134” polymorphisms interaction was higher than the OR of single-locus (OR interaction: 2.11 vs. OR XPC: 1.67), which suggest that this two-way interaction was a superior combination model for the prediction of HCC risk. This evidence concerns the gene ERCC1 and hepatocellular carcinoma.