As shown in Figure 2A and 2B top, the number of pleural (p<0.001) or dissected tumor nodules (p<0.05) was significantly reduced in the Nit1−/−:KrasG12D/+ mice in comparison to Nit1+/+:KrasG12D/+ mice; in addition, the size of tumor nodules are much smaller in Nit1−/−:KrasG12D/+ mice (Figure 2A, 2B middle). This evidence concerns the gene NIT1 and neoplasm.