TP53 and central nervous system cancer: The results from The Cancer Genome Atlas (TCGA) Research Network and several other studies have pinpointed phosphoinositide 3-kinase (PI3K), RTK/RAS/PI3K, EGF receptors (EGFR), p53, retinoblastoma (RB), and PTEN signaling alterations as driving forces for high-grade glioma tumorigenesis [3, 4].