Enhanced PPAP2B in turn, which is known to act as S1P ecto-phosphatase, might impair the S1P-mediated reactivation of tumor cells in autocrine mode via S1PRs and redirect its action to the paracrine manner; approximation of these findings to disease conditions suggests that the S1P effects on stroma and/or immune cells composing the tumor microenvironment thereby might be enhanced. This evidence concerns the gene PLPP3 and neoplasm.