Strikingly, the transcriptional regulator SPDEF was recently shown to act as a tumor metastasis suppressor in vivo [52] and the multifactorial adaptor protein MAD2L2 (also known as MAD2B) was proposed to be involved in the TCF4-mediated epithelial-mesenchymal transdifferentiation [53]. The gene discussed is PROS1; the disease is neoplasm.