In this meta-analyses, five protein-coding variants (SRD5A2 p.Ala49Thr, FGFR4 p.Gly388Arg, HOXB13 p.Gly84Glu, CYP1B1 p.Leu432Val and SOD2 p.Val16Ala) were significantly associated with PCa risk, but the last two variants with small summary ORs (an average of 1.12) had significant between-study heterogeneity (heterogeneity P-value <0.1). The gene discussed is FGFR4; the disease is posterior cortical atrophy.