RRM2 and neoplasm: This was confirmed by real time PCR analysis (Figure 5) showing that one or more Sp TFs decreased expression of the tumor promoting genes ribonucleotide reductase M2 (RRM2) and Aurora kinase A (AURKA) (Figure 5A) and increases expression of the tumor suppressor-like genes such as thioredoxin-interacting protein (TXNIP) and the polycomb CBX7 genes (Figure 5B) [32–35].