Since Rab25 intraperitoneal xenografts harvested five weeks after inculation exhibited higher levels of HIF-1α and VEGF expression than A2780-DNA3 tumours (Figure 5b), the effect of HIF-1 activity on tumorigenicity and invasiveness was investigated by injecting luciferase expressing A2780Rab25-shHIF-1β and SKOV3-shHIF1β cells intraperitoneally as described above. Here, HIF1A is linked to neoplasm.