Rab25 expression in A2780 cells was shown to increase their tumourigenic potential in the peritoneum of immunocompromised mice [19], while SKOV3 cells expressing endogenous Rab25 formed tumours in the peritoneal cavity of nude mice and exhibited elevated levels of HIF-1α expression under non-hypoxic conditions [20]. The gene discussed is HIF1A; the disease is neoplasm.