AKT1 and central nervous system cancer: Furthermore, quercetin has been reported to promotes cell apoptosis and in human glioma cell lines by the suppression of PI-3-kinase-Akt and ERK signalling pathways [57, 58] and induce radiosensitization in tumor cells other than medulloblastoma by targeting the ATM-mediated pathway, which is critical in the DNA damage response [59].